Pulmonary Mycobacterium avium infection in an immunocompetent young adult related to use of home bath with a circulating water system.

نویسندگان

  • A Watando
  • E Toyota
  • N Mori
  • A Kaneko
  • T Kuratsuji
  • T Kirikae
  • K Kudo
چکیده

Branchburg, NJ・, USA), the sputum was positive f♭r 〟. avium. It was, however, negative for M. tuberculosis and M. intracellulare. The bronchial asplrateS Were AFBand M. avium complex (MAC) culture positive. Four drug chemotherapy consistlng Of clarithromycln, rifampln, Streptomycin, and ethambutol was started immediately. The MAC isolate was resistant torifampin (MIC: >50 LLg/ml), streptomycin (MIC: >20 LLg/ml), and ethambutol (MIC: >5 LLg/ml), but relatively sensitive to clarithromycin(MIC: 4 LLg/ml). ARer 3 months of treatment, she became asymptomatic, and her chest radiograph and CT scan improved. The patient and her family used a bath with a circulating and filterlng Water System in their home. The bath water was found MAC culture positive. PCR-based diagnosis revealed that the MACs both from the bath water and the patient were M. avium. To determine whether these isolates were derived from a clone, chromosomal DNA's derived from these two isolates and two more M. avium clinical isolates not associated with the present case were analyzed by pulsed-field gel electrophoresis (PFGE) (CHEF MapperTM: Bio-Rad Laboratories, Hercules, Calif., USA) of Asel digests (Fig. 2), IS1245

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عنوان ژورنال:
  • Japanese journal of infectious diseases

دوره 54 4  شماره 

صفحات  -

تاریخ انتشار 2001